Makeworthy Media

Disables WordPress from generating image thumbnails when you upload a PDF. This behavior was introduced in WordPress 4.7, so this plugin isn’t needed for any version older than that. Not all web hosts support the ability to generate images from PDFs either, so even if you have 4.7 or newer you might not need this.

Disable PDF Thumbnails

Disables WordPress from generating image thumbnails when you upload a PDF.

thaikolja

Thumbnails Cleaner helps you keep your WordPress installation tidy by removing and regenerating thumbnails.
You can control all functions through the plugins’ main page found under “Tools”. You can:
<ul>
<li>Analyze your uploads directory, giving you an overview how many original files and thumbnails there are.</li>
<li>Clean thumbnails which means deleting them while keeping the original files.</li>
<li>Restore thumbnails to start out with a clean uploads directory. This function requires the plugin <a href="https://wordpress.org/plugins/regenerate-thumbnails/" rel="ugc">Regenerate Thumbnails</a>.</li>
<li>Create backups of your uploads directory to keep your files safe in the unlikely event that there is a problem.</li>
<li>Restore backups in case you have lost a file that was not supposed to be deleted.</li>
</ul>
Please see the <a href="https://www.koljanolte.com/wordpress/plugins/thumbnail-cleaner/documentation/" rel="nofollow ugc">official website</a> for a full 
documentation.

Thumbnail Cleaner

Cleans up your WordPress installation by removing and regenerating thumbnails.

Disable PDF Thumbnails vs Thumbnail Cleaner