Raven’s antispam – powerful and invisible fighter against comment spam. No set-up necessary, install and forget.
<h4>Details</h4>
Visitors with enabled JavaScript (99%+) see nothing – no annoying questions, no captcha, nothing. (Users with disabled JS see an additional text-field and a word that must be rewritten into the textfield.)
Note: this plugin is not able to check your trackbacks – to handle trackback spam, it’s necessary to use some other solution. (I recommend to disable trackbacks globally, since they rarely bring any benefit for your readers.) <a href="http://kahi.cz/wordpress/ravens-antispam-plugin/" rel="nofollow ugc">more…</a>.

Raven's Antispam

Powerful and invisible fighter against comment spam.

Huda Toriq

CommentMailer is a WordPress plugin that generates and sends e-mail to your blog’s commenters to tell them that you 
have replied his/her comment on your blog’s comment system. It adds extra options on your blog’s comment form to select 
which commenters you are replying to. Submitting the reply comment will trigger the e-mail generation function thus 
send them automatically. You can customize your own notification e-mail or use the default one.

CommentMailer

Send automated email to your blog's commenters everytime you reply their comments on the blog's comment system.

Raven's Antispam vs CommentMailer