You can press CTRL+S in ANY browser to save the work you’re working with, including posts and pages.
Some features:
<ul>
<li>Saves your current work by pressing CTRL+S</li>
<li>Works in all browsers (thanks <a href="http://www.openjs.com/" title="Open JS" rel="nofollow ugc">Binny V A</a>)</li>
<li>No jQuery</li>
<li>Made in Sweden</li>
</ul>

The Saver

This plugins allows you to publish your posts/pages and update your files in the admin panel by pressing CTRL+S.

Mindvalley

A framework to add additional shortcut keys to the post editor page.
E.g.
<ul>
<li>Ctrl+Alt+p = Publish</li>
<li>Ctrl+Alt+s = Save Draft</li>
<li>Ctrl+Alt+l = Preview</li>
</ul>
Modify key mappings under Settings > MV Shortcut.
Works on PC and Mac.

MindValley Shortcut Framework

Collection of Additional Keyboard Shortcuts for Post Editor page.

The Saver vs MindValley Shortcut Framework