Speedboxer

This plugin will convert valid <a href="http://twitter.com/" title="Twitter" rel="nofollow ugc">Twitter</a> usernames mentioned in comments into a link to their Twitter profile page. For example, if somebody mentions “@mattfreedman” in their comment, this plugin will check with Twitter to see if the user “mattfreedman” exists (which is does) and when it does, it will convert it into “<a href="http://twitter.com/mattfreedman" rel="nofollow ugc">@mattfreedman</a>“.
Please note: As this plugin converts usernames on the fly (whenever and everytime somebody views the comments), and checks Twitter for every username (to ensure it’s valid), I strongly recommend using a caching plugin such as <a href="https://wordpress.org/extend/plugins/wp-super-cache/" title="WP Super Cache" rel="ugc">WP Super Cache</a>. Which will not only lessen the load on Twitter’s servers, but also speed up page loads.
Although it says this plugin requires WordPress 2.6, I see no reason why it wouldn’t work with earlier versions, I just haven’t tested it with earlier version.
This plugin requires cURL to be installed on your server, and has only been tested with PHP 5.2.x.

Twitter Links

Converts Twitter usernames mentioned in comments (eg. @mattfreedman) with a link to the mentioned user's Twitter profile page.

neon

If you write something like “@nick, how are you?” this plugin will search for @nick’s url in the comment list of the current post and will convert his/her name to a link.

Twitter style links

This plugin allows you to add Twitter style links to comments.

Twitter Links vs Twitter style links