Aaron Butacov

<a href="http://aahacreative.com/our-projects/wordpress-quick-save/" rel="nofollow ugc">WordPress Quick Save</a> adds a CTRL+S keyboard shortcut to trigger the Auto-save functionality in WordPress. If you find that you habitually hit CTRL+S while writing posts, this will stop those annoying popup save site windows from appearing.
No more having to stop and click save to ensure you don’t lose your recent edits. Keep in mind, this saves ONLY as an autosave.
This plugin should work with most versions of WordPress, but has not been tested in versions earlier than 2.9
<ul>
<li>Works in all major browsers.</li>
</ul>

WordPress Quick Save

Do you habitually press CTRL+S when writing? Do you fear missing posts? There's help!

You can press CTRL+S in ANY browser to save the work you’re working with, including posts and pages.
Some features:
<ul>
<li>Saves your current work by pressing CTRL+S</li>
<li>Works in all browsers (thanks <a href="http://www.openjs.com/" title="Open JS" rel="nofollow ugc">Binny V A</a>)</li>
<li>No jQuery</li>
<li>Made in Sweden</li>
</ul>

The Saver

This plugins allows you to publish your posts/pages and update your files in the admin panel by pressing CTRL+S.

WordPress Quick Save vs The Saver