Aaron Butacov

<a href="http://aahacreative.com/our-projects/wordpress-quick-save/" rel="nofollow ugc">WordPress Quick Save</a> adds a CTRL+S keyboard shortcut to trigger the Auto-save functionality in WordPress. If you find that you habitually hit CTRL+S while writing posts, this will stop those annoying popup save site windows from appearing.
No more having to stop and click save to ensure you don’t lose your recent edits. Keep in mind, this saves ONLY as an autosave.
This plugin should work with most versions of WordPress, but has not been tested in versions earlier than 2.9
<ul>
<li>Works in all major browsers.</li>
</ul>

WordPress Quick Save

Do you habitually press CTRL+S when writing? Do you fear missing posts? There's help!

Chad Hovell

Select extra layouts from the post editor Screen Options menu. 
There are now 24 variations to choose from!

Three Column Screen Layout

Three, four and five column screen layouts for the post editor.

WordPress Quick Save vs Three Column Screen Layout