Comment blacklisting works well, but what if you actually want to stop someone from even reading your blog? This plugin will take care of that for you.
It uses .htaccess file modifications to deny access to your blog from particular IP addresses (Deny from) and then follows up with an ErrorDocument 403 redirect to a URL of your choice. It doesn’t hook into WordPress, which makes it a lot faster due to no database or PHP calls.

WP-BlockYou

A plugin that can be used to block or "ban" users via their IP address from viewing your blog, and then redirecting them to a URL of your ch …

jamiechong

A lot of registration spam comes from emails with a subdomain. Spammers control a domain such as buymyjunk.com and then attempt to register on your site with emails such as irenemwd@foster2.buymyjunk.com and jakemgm@foster7.buymyjunk.com. This plugin simply blocks all registrations using a subdomain.
Reputable users will have a normal email address from a reasonable domain like @gmail.com, @mylegitbusiness.com, @outlook.com, @myschool.edu, etc.
There is no configuration and no setup. It simply just works. The plugin logs all blocked registrations so you can find potential false-positives. Find a link to this log file on the Plugins page where you activate/deactivate this plugin.

Ban Subdomain Emails

Prevent people from registering with emails that contain a subdomain to help reduce spam.

WP-BlockYou vs Ban Subdomain Emails