pressedsites

<a href="http://pressedsites.com/wordpress-save-hijack/" rel="nofollow ugc">WordPress Save Hijack</a> 
Adds a keyboard shortcut to trigger the Publish/Update functionality in WordPress posts.
This plugin should work with most versions of WordPress
<ul>
<li>Works in all major browsers. (on osx anyway please give feedback if find different on windows)</li>
</ul>

WordPress Save Hijack

Enables keyboard shortcuts for saving post edits (ie. cmd+s / ctrl+s)

You can press CTRL+S in ANY browser to save the work you’re working with, including posts and pages.
Some features:
<ul>
<li>Saves your current work by pressing CTRL+S</li>
<li>Works in all browsers (thanks <a href="http://www.openjs.com/" title="Open JS" rel="nofollow ugc">Binny V A</a>)</li>
<li>No jQuery</li>
<li>Made in Sweden</li>
</ul>

The Saver

This plugins allows you to publish your posts/pages and update your files in the admin panel by pressing CTRL+S.

WordPress Save Hijack vs The Saver