pressedsites

<a href="http://pressedsites.com/wordpress-save-hijack/" rel="nofollow ugc">WordPress Save Hijack</a> 
Adds a keyboard shortcut to trigger the Publish/Update functionality in WordPress posts.
This plugin should work with most versions of WordPress
<ul>
<li>Works in all major browsers. (on osx anyway please give feedback if find different on windows)</li>
</ul>

WordPress Save Hijack

Enables keyboard shortcuts for saving post edits (ie. cmd+s / ctrl+s)

Chad Hovell

Select extra layouts from the post editor Screen Options menu. 
There are now 24 variations to choose from!

Three Column Screen Layout

Three, four and five column screen layouts for the post editor.

WordPress Save Hijack vs Three Column Screen Layout